TIAM1-Rac1信号轴在胰腺癌进展中的作用及靶向策略研究进展

The TIAM1-Rac1 axis in pancreatic cancer progression: mechanisms and therapeutic implications

摘要:

T细胞淋巴瘤侵袭和转移诱导因子1（TIAM1）是一种特异性鸟苷酸交换因子，在多种肿瘤的发生发展中发挥重要作用。近年来研究表明，TIAM1在胰腺癌中呈高表达状态，并与肿瘤的增殖、侵袭、转移及不良预后密切相关。本文围绕TIAM1在胰腺癌中的研究进展，系统综述其基本结构与生物学功能，重点阐述TIAM1-Rac1信号轴及其与Wnt/β-catenin、RhoA等通路的交互作用，以及其在调控细胞骨架重塑、上皮-间充质转化（EMT）和代谢重编程中的分子机制。同时，总结TIAM1在胰腺癌免疫微环境中的潜在作用，并探讨其作为预后标志物及治疗靶点的研究价值。深入解析TIAM1相关分子网络，有助于为胰腺癌的精准治疗提供理论依据和新的干预策略。

Abstract:

T-cell lymphoma invasion and metastasis-inducing factor 1 (TIAM1) is a guanine nucleotide exchange factor (GEF) that plays a crucial role in tumorigenesis and progression. Increasing evidence has demonstrated that TIAM1 is highly expressed in pancreatic cancer and is closely associated with tumor proliferation, invasion, metastasis, and poor prognosis. This review summarizes the current advances in understanding the biological functions and molecular mechanisms of TIAM1 in pancreatic cancer. Particular emphasis is placed on the TIAM1-Rac1 signaling axis and its crosstalk with Wnt/β-catenin and RhoA pathways, as well as its roles in cytoskeletal remodeling, epithelial–mesenchymal transition (EMT), and metabolic reprogramming. In addition, the potential involvement of TIAM1 in shaping the tumor immune microenvironment is discussed. TIAM1 may serve as a promising prognostic biomarker and therapeutic target, and further elucidation of its regulatory network could provide novel insights for precision therapy in pancreatic cancer.