脉管性疾病ISSVA 2025版分类解读

Interpretation of the 2025 ISSVA classification for vascular anomalies

摘要:

国际脉管异常研究学会（ISSVA）分类系统是目前全球通用的脉管异常多学科诊疗“金标准”。自1996年首次发布以来历经多次修订，2014年和2018年两次更新显著推动了临床规范化诊疗。2025年随着基因组学、分子影像技术的突破，ISSVA发布新一版分类修订，反映了对脉管性疾病从形态学到分子机制的认知深化。主要变化体现在整体结构和分类方式上。主体表格内容更加简洁，由1个基础分类界面和3个详细分类页面组成，适用于分级诊疗；并推出全新的词汇表。另外，从之前按照临床表型进行分类，到从临床、病理、血流动力和基因四个方面进行综合分析和分类，2025版对全球脉管疾病的诊疗标准化具有里程碑意义。本文就2025版ISSVA新分类作一介绍和解读，希望能让广大医疗工作者深入理解新版分类、紧跟指南优化诊疗策略，改善患者预后。

Abstract:

The International Society for the Study of Vascular Anomalies (ISSVA) classification system is currently the globally accepted multidisciplinary "golden standard". Since its initial release in 1996, it has undergone multiple revisions, with significant updates in 2014 and 2018 substantially advancing standardized clinical diagnosis and treatment. In 2025, breakthroughs in genomics and molecular imaging technology prompted ISSVA to release a new version of the classification, reflecting a deepened understanding of vascular anomalies from morphology to molecular mechanisms. The main changes are evident in the overall structure and classification approach. The core table content is more concise, consisting of one basic classification interface and three detailed classification pages, suitable for tiered healthcare; a new glossary has also been introduced. Furthermore, shifting from the previous classification based on clinical phenotype to a new classification considering the clinical presentation, histological subtypes, flow velocity, and genetic aspects, the 2025 edition holds milestone significance for standardizing the global diagnosis and treatment of vascular anomalies. This article provides an introduction and interpretation of the 2025 ISSVA classification, aiming to help healthcare professionals gain an in-depth understanding of the new classification system, follow updated guidelines to optimize diagnosis and treatment strategies, and ultimately improve patient outcomes.