急性胰腺炎肠道微生物组研究的文献计量与趋势分析

Bibliometric and trend analysis of gut microbiome studies in acute pancreatitis

摘要:

背景与目的 急性胰腺炎（AP）病程异质性显著，重症患者病死率较高。近年来研究表明，肠道微生物组在AP发生发展中发挥重要作用，但缺乏系统的文献计量学分析以揭示该领域研究格局与发展趋势。本研究基于文献计量学方法，对AP肠道微生物组研究进行系统分析。方法 检索Web of Science核心合集数据库（2012年1月—2026年2月），纳入AP与肠道微生物组相关的英文Article和Review。采用CiteSpace和VOSviewer进行国家、机构、作者、期刊及关键词的共现与聚类分析，并利用GraphPad Prism绘制发文趋势。结果 共纳入文献184篇。发文量总体呈持续增长趋势，2019年后进入快速发展阶段。中国发文量居首（141篇），主要研究机构亦集中于中国。Frontiers in Microbiology为发文量最多的期刊，Gut为被引频次最高期刊。研究热点主要集中于肠道菌群失调与疾病严重程度、肠屏障功能、肠内营养及代谢产物（如短链脂肪酸、胆汁酸）等方面。关键词聚类显示，AP相关并发症、肠屏障损伤及营养干预为当前研究重点。结论 AP肠道微生物组研究处于快速发展阶段，中国在该领域具有重要影响力。未来研究应进一步聚焦肠道微生态紊乱、肠屏障损伤及细菌易位的相互作用机制，并结合多组学与人工智能方法，推动基于“肠-胰轴”的精准诊疗策略发展。

Abstract:

Background and Aims Acute pancreatitis (AP) is a heterogeneous disease with considerable mortality in severe cases. Increasing evidence highlights the critical role of the gut microbiome in AP progression; however, comprehensive bibliometric analyses in this field remain limited. This study aimed to systematically evaluate the research landscape and emerging trends of gut microbiome studies in AP.Methods Publications from January 2012 to February 2026 were retrieved from the Web of Science Core Collection. English articles and reviews related to AP and the gut microbiome were included. CiteSpace and VOSviewer were used to perform co-occurrence and clustering analyses of countries, institutions, authors, journals, and keywords. Publication trends were analyzed using GraphPad Prism.Results A total of 184 publications were included. The number of publications has increased steadily, with a rapid growth phase after 2019. China contributed the largest number of publications (n=141), and leading institutions were predominantly from China. Frontiers in Microbiology was the most productive journal, while Gut had the highest citation impact. Research hotspots mainly focused on gut microbiota dysbiosis and disease severity, intestinal barrier function, enteral nutrition, and microbiota-derived metabolites such as short-chain fatty acids and bile acids. Keyword clustering further highlighted complications of AP, intestinal barrier injury, and nutritional interventions as major research themes.Conclusion Research on the gut microbiome in AP is in a rapid development phase, with China playing a leading role. Future studies should focus on the interactions among gut microbiota dysbiosis, intestinal barrier dysfunction, and bacterial translocation, and integrate multi-omics and artificial intelligence approaches to advance precision medicine based on the gut-pancreas axis.