RhoA/ROCK信号通路在急性胰腺炎中的作用机制研究进展

The role and mechanisms of the RhoA/ROCK signaling pathway in acute pancreatitis: research progress

摘要:

急性胰腺炎（AP）是一种具有较高发病率和病死率的消化系统急症，其病理机制复杂，涉及多种信号通路。其中，RhoA/ROCK信号通路在AP的发生和发展过程中发挥着关键作用，影响胰腺炎症反应、纤维化、微循环调控及与其他信号通路的相互作用。研究表明，抑制RhoA/ROCK信号通路可有效缓解AP病情，降低炎症因子水平，并改善胰腺微循环，为AP的治疗提供了新的思路，有望成为未来的重要治疗策略。因此，本文系统梳理了RhoA/ROCK信号通路的结构与功能，重点探讨其在AP进程中的作用机制，并进一步分析其在临床治疗中的潜在应用价值。通过整合现有研究成果，本文旨在为深入理解该信号通路在AP中的作用提供新视角，同时为未来的基础研究和临床应用提供理论依据。

Abstract:

Acute pancreatitis (AP) is a severe digestive system emergency characterized by high morbidity and mortality, with a complex pathogenesis involving multiple signaling pathways. Among them, the RhoA/ROCK signaling pathway plays a crucial role in the onset and progression of AP, influencing pancreatic inflammation, fibrosis, microcirculatory regulation, and interactions with other signaling pathways. Studies have shown that inhibiting the RhoA/ROCK signaling pathway can effectively alleviate AP severity, reduce inflammatory cytokine levels, and improve pancreatic microcirculation, offering new therapeutic insights and potential strategies for AP treatment. Therefore, this review systematically summarizes the structure and function of the RhoA/ROCK signaling pathway, explores its mechanistic role in AP progression, and further discusses its potential clinical applications. By integrating existing research findings, this paper aims to provide new perspectives on the role of this signaling pathway in AP and offer a theoretical foundation for future basic research and clinical applications.