肝叶切除治疗复杂医源性胆管损伤1例报告并文献复习
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山西医科大学第二临床医学院/山西医科大学第二医院 普通外科,山西 太原 030001

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李贺鹏,山西医科大学第二临床医学院/山西医科大学第二医院硕士研究生,主要从事普通外科及肝胆胰方面的研究。

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Hepatic lobectomy for complex iatrogenic bile duct injury: a case report and review of the literature
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Department of General Surgery, the Second School of Clinical Medicine, Shanxi Medical University/the Second Affiliated Hospital, Shanxi Medical University, Taiyuan 030001, China

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    摘要:

    医源性胆管损伤(IBDI)是常见的胆管损伤类型,多发生于胆囊切除术。随着腹腔镜胆囊切除术的普及,其发生率明显高于开腹手术,且合并血管损伤(VI)的复杂病例逐渐增多,增加了诊治难度,严重时可导致肝缺血及萎缩。肝管空肠吻合术是胆管损伤后常用的重建方式,若合并VI,则可能需行肝切除。本文报告笔者收治的1例53岁女性患者,因胆囊切除术后出现胆汁漏入院。经2次多学科团队(MDT)讨论,术前评估显示肝右动脉及门静脉分支损伤并伴右前叶萎缩。根据术中所见,最终实施右半肝切除联合左肝管空肠Roux-en-Y吻合术。患者术后恢复顺利,随访6个月无明显不适。通过对该病例的诊治过程及文献的回顾与分析,本文总结了复杂IBDI的临床特点、诊治策略及MDT模式的价值,以期为临床实践提供借鉴。

    Abstract:

    Iatrogenic bile duct injury (IBDI) is a common type of bile duct injury, most frequently occurring during cholecystectomy. With the widespread use of laparoscopic cholecystectomy, its incidence is significantly higher than that of open surgery, and the number of complex cases combined with vascular injury (VI) has been increasing, posing greater challenges for diagnosis and treatment. In severe cases, it may result in hepatic ischemia and atrophy. Hepaticojejunostomy is the standard reconstructive procedure after bile duct injury, whereas hepatectomy may be required when VI is involved. We report the case of a 53-year-old woman who was admitted with bile leakage following cholecystectomy. After two multidisciplinary team (MDT) discussions, preoperative evaluation revealed injury to the right hepatic artery and a portal vein branch, accompanied by atrophy of the right anterior lobe. Based on intraoperative findings, the patient underwent right hepatectomy combined with Roux-en-Y hepaticojejunostomy of the left hepatic duct. Postoperative recovery was uneventful, and the patient remained symptom-free during a 6-month follow-up. By reviewing the diagnosis and management of this case in conjunction with relevant literature, we summarize the clinical features, treatment strategies, and the value of MDT management in complex IBDI, aiming to provide reference for clinical practice.

    图1 第1次入院影像学资料 A:上腹部增强CT动脉期,肝左动脉及分支(箭头所示)显影,肝右动脉未显影;B:上腹部增强CT门脉期,门静脉右后支(箭头所示)显影,门静脉右前支未显影;C:MRCP可见肝右叶胆管走行区异常信号,Glission鞘肿胀;D:引流管造影提示三支分离(右前叶肝管、右后叶肝管及左肝管)(箭头所示),肝管汇合部及下段肝总管及胆总管分支未显影Fig.1 Imaging findings at the first admission A: Enhanced CT of the upper abdomen in the arterial phase shows visualization of the left hepatic artery and its branches (arrow), while the right hepatic artery is not visualized; B: Enhanced CT of the upper abdomen in the portal phase shows visualization of the right posterior branch of the portal vein (arrow), while the right anterior branch is not visualized; C: MRCP reveals abnormal signal in the bile duct tract of the right hepatic lobe with swelling of the Glisson sheath; D: Drainage tube cholangiography suggests separation of three branches (right anterior hepatic duct, right posterior hepatic duct, and left hepatic duct) (arrow), while the confluence of the hepatic ducts, lower common hepatic duct, and branches of the common bile duct are not visualized
    图2 第2次入院影像学资料 A:腹部增强CT动脉期可见肝右动脉侧支循环(箭头所示);B:上腹部MRCP可见右肝前叶萎缩,胆管扩张,左肝代偿性增大;C:术前造影仍示三支分离(右前叶肝管、右后叶肝管及左肝管)(箭头所示),同时可见肝门与椎体右缘距离增宽,提示肝门逆钟向转位Fig.2 Imaging findings at the second admission A: Enhanced CT of the abdomen in the arterial phase shows collateral circulation of the right hepatic artery (arrow); B: Upper abdominal MRCP demonstrates atrophy of the right anterior lobe of the liver, dilated bile ducts, and compensatory hypertrophy of the left liver; C: Preoperative cholangiography still shows separation of three branches (right anterior hepatic duct, right posterior hepatic duct, and left hepatic duct) (arrow), with widening of the distance between the hepatic hilum and the right margin of the vertebral body, suggesting retrograde clockwise transposition of the hilum
    图3 术中图片 A:肝脏右前叶萎缩;B:左肝管开口(箭头所示)Fig.3 Intraoperative findings A: Atrophy of the right anterior lobe of the liver; B: Opening of the left hepatic duct (arrow)
    图4 术后U形管造影 A:胆肠吻合口少量造影剂漏(虚线所示),大量造影剂流入远端小肠肠管;B:造影剂顺利流入远端肠管Fig.4 Postoperative U-tube cholangiography A: A small amount of contrast leakage is observed at the bilioenteric anastomosis (dotted line), with most of the contrast agent flowing into the distal small intestine; B: The contrast agent flows smoothly into the distal intestinal tract
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李贺鹏,苏俊彦,商中华.肝叶切除治疗复杂医源性胆管损伤1例报告并文献复习[J].中国普通外科杂志,2025,34(7):1489-1497.
DOI:10.7659/j. issn.1005-6947.240614

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  • 收稿日期:2024-11-27
  • 最后修改日期:2025-02-06
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  • 在线发布日期: 2025-09-02