胰腺外分泌功能不全的病因、诊断及治疗进展

Advances in the etiology, diagnosis, and treatment of exocrine pancreatic insufficiency

摘要:

胰腺外分泌功能不全（EPI）是一种由于胰液及其消化酶，尤其是胰脂肪酶的分泌或活性减少所引发的疾病。EPI可导致腹痛、腹胀、脂肪泻、营养不良和体质量减轻，甚至可能增加骨质疏松和心血管疾病的风险。其诊断主要依赖于直接功能检测和间接功能检测，治疗以胰酶替代治疗为核心，结合综合管理策略。本文对EPI的定义、常见病因、现有诊断方法及治疗与预防策略的研究进展进行了归纳总结，以期为该疾病的诊治优化提供参考。

Abstract:

Exocrine pancreatic insufficiency (EPI) is a condition caused by a reduction in the secretion or activity of pancreatic juice and its digestive enzymes, particularly pancreatic lipase. EPI can lead to symptoms such as abdominal pain, bloating, steatorrhea, malnutrition, and weight loss, and may even increase the risk of osteoporosis and cardiovascular diseases. Diagnosis mainly relies on direct and indirect functional tests, while treatment is centered on pancreatic enzyme replacement therapy combined with comprehensive management strategies. This article summarizes the research progress on the definition, common causes, diagnostic methods, treatment, and prevention strategies of EPI, aiming to provide insights for optimizing its diagnosis and management.