结直肠癌患者IL-6基因启动子-174G→C多态性研究

Investigation of -174G→C polymorphism of the IL-6 gene promoter in patients with colorectal cancer

摘要:

目的：观察结直肠癌患者是否存在IL-6基因启动子-174G→C位点的多态性。
方法：采用PCR扩增、限制性内切酶片段长度多态性（RFLP）分析判断46例结直肠患者IL-6启动子-174G→C多态性。
结果：全组结直肠癌患者IL-6基因启动子-174位点均为GG型。
结论：本组结直肠癌患者中未发现IL-6基因启动子-174位点的多态性。

Abstract:

Abstract:Objective：To detect -174G→C polymorphism of IL-6 gene promoter in patients with colorectal cancer.
Methods ：-174G→C polymorphism of IL-6 gene promoter was detected by PCR-RFLP in 49 patients with colorectal cancer.
Results：-174G→C polymorphism of IL-6 gene promoter in all the 46 patients with colorectal cancer was -174G/G genotype.
Conclusions：-174G→C polymorphism of IL-6 gene promoter was not found in 49 patients with colorectal cancer.