肝动脉化疗栓塞对原发性肝癌患者术后生存及肿瘤复发的影响

Study on the effects of TACE on recurrence and post-operative survival rates for primary hepatocellular carcinoma patients

摘要:

目的： 探讨原发性肝癌患者手术后肝动脉化疗栓塞（TACE）对肿瘤复发率及患者术后生存率的影响，为原发性肝癌的临床综合治疗提供指导。
方法：原发性肝癌患者手术后行TACE治疗22例（手术＋TACE组）、仅行手术切除而不行TACE治疗患者20例（单纯手术组），对两组患者术后肿瘤复发率及患者生存率进行比较。
结果：手术+TACE组与单纯手术组比较，前者肿瘤1年复发率显著低于后者（P<0.05），但两组2年复发率差异无显著性（P>0.05）。手术＋TACE组1年及2年生存率（76.1％，48.2％）均明显高于单纯手术组（52.8％，23.6％）（P<0.05）。结论：原发性肝癌手术后结合TACE治疗，可明显降低肿瘤近期复发率且显著提高患者生存率。

Abstract:

Abstract:Objective：To investigate the effects of TACE in preventing post-operative tumor recurrence and increasing survival rate for primary hepatocellular cancer patients.
Methods ：Forty two patients with primary hepatocellular cancer were studied in this research. Transcatheter arterial chemoembolization (TACE) was performed in 22 patients after operation but not in the other 20 patients. The post-operative recurrence rate of the tumors and the survival rate of the patients were compared between the two groups.
Results：In TACE group, the tumor recurrence rate within one year after operation was remarkably lower than that of the control group(P<0.05). But there was no significant difference in the tumor recurrence rate two years after operation between the two groups(P>0.05). The one-year survival rate (76.1％) and two-year survival rate(48.2％) of TACE group were both significantly higher than those of the control group(52.8％,23.6％)(P<0.05).
Conclusions：Transcatheter arterial chemoembolization after operation could remarkably decrease the tumor recurrence rate and increase post-operative survival rate.