急性胰腺炎腺泡细胞损伤机制研究进展

Mechanism for injury of pancreatic acinar cells during acute pancreatitis: recent progress

摘要:

急性胰腺炎（AP）是胰腺的炎症性疾病，由于发病机制尚未完全阐明，临床对重症AP仍缺乏有效的治疗方法。目前认为，钙超载、酶原异常活化、内质网应激、自噬、线粒体损伤及炎症反应与胰腺腺泡细胞损伤关系密切，现就其研究进展进行综述。

Abstract:

Acute pancreatitis (AP) is an inflammatory disorder of the pancreas. Because the mechanism is not yet fully elucidated, there is clinically no effective treatment for the severe AP. Calcium overload, premature trypsinogen activation, endoplasmic reticulum stress, autophagy, mitochondrial dysfunction and inflammatory response are considered to be closely associated with the injury of pancreatic acinar cells. Here, the authors address the research progress in this field.