Objective: To investigate the application of hybrid procedure in treatment of complex aortic diseases. Methods: The clinical data of the 12 patients with complex aortic disease undergoing hybrid treatment from August 2007 to August 2012 were retrospectively analyzed. Of the patients, 9 cases had aortic dissection, and 3 cases had thoracoabdominal aortic aneurysm. The procedures included various prosthetic bypass graftings combined with endovascular covered stent placement. Results: Technical success was achieved in all patients. Proximal type I endoleak occurred in one patient with aortic dissection after operation, for which no treatment was given; one patients with aortic dissection died during perioperative period due to severe mediastinal infection; the rest of the patients recovered well after operation. Follow-up was obtained in 8 patients for 3 months to 2 years, and all of them were alive without endoleak or other complications. Conclusion: Hybrid procedure is a viable alternative to patients with complex aortic diseases.