Abstract:Compression therapy is a physical treatment modality that applies continuous or intermittent pressure to specific body regions using compression devices to improve venous and lymphatic return, reduce edema, alleviate symptoms, and promote wound healing. It plays an essential role in the management of venous and lymphatic disorders. However, challenges remain in China, including insufficient high-quality evidence, lack of unified product standards, and non-standardized clinical practice, and evidence-based clinical practice guidelines are still lacking. To address these issues, the Pressure Group of the Peripheral Vascular Disease Professional Committee of the Chinese Society of Microcirculation organized experts from 17 major tertiary hospitals nationwide. Following the Guiding Principles for Developing/Revising Clinical Practice Guidelines in China (2022 Edition) and the RIGHT statement for reporting practice guidelines, the panel developed 32 clinical questions across eight key topic areas. Evidence quality and recommendation strength were assessed using the GRADE approach, and expert consensus was achieved through the Delphi method, resulting in 53 recommendations. This guideline aims to standardize compression therapy for venous and lymphatic diseases in China, improve the scientific rigor and consistency of clinical practice, and promote further research and evidence-based application in this field.