Abstract:The International Society for the Study of Vascular Anomalies (ISSVA) classification system is currently the globally accepted multidisciplinary "golden standard". Since its initial release in 1996, it has undergone multiple revisions, with significant updates in 2014 and 2018 substantially advancing standardized clinical diagnosis and treatment. In 2025, breakthroughs in genomics and molecular imaging technology prompted ISSVA to release a new version of the classification, reflecting a deepened understanding of vascular anomalies from morphology to molecular mechanisms. The main changes are evident in the overall structure and classification approach. The core table content is more concise, consisting of one basic classification interface and three detailed classification pages, suitable for tiered healthcare; a new glossary has also been introduced. Furthermore, shifting from the previous classification based on clinical phenotype to a new classification considering the clinical presentation, histological subtypes, flow velocity, and genetic aspects, the 2025 edition holds milestone significance for standardizing the global diagnosis and treatment of vascular anomalies. This article provides an introduction and interpretation of the 2025 ISSVA classification, aiming to help healthcare professionals gain an in-depth understanding of the new classification system, follow updated guidelines to optimize diagnosis and treatment strategies, and ultimately improve patient outcomes.