Abstract:In recent years, with the increasingly wide application of indocyanine green (ICG) fluorescence navigation technique in various medical fields, it has grown more mature, especially its development in laparoscopic hepatobiliary and pancreatic surgery. The application of ICG in liver surgery mainly includes defining the boundaries of liver tumor lesions, discovering small lesions, detecting residual lesions at the resection margin, real-time marking of liver segments and surgical liver planes, which is beneficial to reduce the risk of surgery and improve the R0 resection rate; in biliary tract surgery mainly involves the resection of the intrahepatic cholangiocarcinoma and gallbladder, identifying intraoperative bile leakage, avoiding bile duct damage, and reducing the incidence of postoperative complications. ICG imaging combined with laparoscopic pancreaticoduodenectomy (LPD) can accurately determine the anatomical positional relationship between pancreatic tumors and blood vessels, and locate lymph node metastasis during surgery, providing surgeons with beneficial real-time visual information. Here, the authors summarize the application of ICG combined with laparoscopic techenique in hepatobiliary and pancreatic surgery.